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1

Language convergence and wave phenomena in the growth of a national sign language in Kenya

OKOMBO, D. O., AKACH, P. O.

Journal:

International Journal of the Sociology of Language

Year:

1997

Language:

english

File:

PDF, 1.55 MB

english, 1997

2

Sign Language, Democracy and Deafness in Africa

Journal:

Language Matters

Year:

1999

Language:

english

File:

PDF, 910 KB

english, 1999

3

Synthesis and biological characterisation of ester and amide derivatives of Fusidic acid as antiplasmodial agents

Singh, Kawaljit, Espinoza-Moraga, Marlene, Njoroge, Mathew, Kaur, Gurminder, Okombo, John, De Kock, Carmen, Smith, Peter J., Wittlin, Sergio, Chibale, Kelly

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 474 KB

english, 2016

4

Oxalate content of selected pasta products

Michael Liebman, Joseph Okombo

Journal:

Journal of Food Composition and Analysis

Year:

2009

Language:

english

File:

PDF, 85 KB

english, 2009

5

Oxalate content of selected breads and crackers

Joseph Okombo, Michael Liebman

Journal:

Journal of Food Composition and Analysis

Year:

2010

Language:

english

File:

PDF, 99 KB

english, 2010

6

Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate

Nzila, A., Okombo, J., Molloy, A. M.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2014

Language:

english

File:

PDF, 250 KB

english, 2014

7

Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-haematin Formation

Okombo, John, Singh, Kawaljit, Mayoka, Godfrey, Ndubi, Ferdinand, Barnard, Linley, Njogu, Peter M., Njoroge, Mathew, Gibhard, Liezl, Brunschwig, Christel, Vargas, Mireille, Keiser, Jennifer, Egan, Tim

Journal:

ACS Infectious Diseases

Year:

2017

Language:

english

File:

PDF, 533 KB

english, 2017

8

Structure-activity relationship studies and Plasmodium life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles which are efficacious in an in vivo mouse model of malaria.

Mayoka, Godfrey, Njoroge, Mathew, Okombo, John, Gibhard, Liezl, Sanches-Vaz, Margarida, Fontinha, Diana, Birkholtz, Lyn-Marie, Reader, Janette, van der Watt, Mariëtte, Coetzer, Theresa L., Lauterbach,

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.73 MB

english, 2018

9

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

Kim, Jonathan, Tan, Yong Zi, Wicht, Kathryn J., Erramilli, Satchal K., Dhingra, Satish K., Okombo, John, Vendome, Jeremie, Hagenah, Laura M., Giacometti, Sabrina I., Warren, Audrey L., Nosol, Kamil, R

Journal:

Year:

2019

File:

PDF, 17.10 MB

2019

10

Probiotic-induced reduction of gastrointestinal oxalate absorption in healthy subjects

Joseph Okombo, Michael Liebman

Journal:

Year:

2010

Language:

english

File:

PDF, 253 KB

english, 2010

11

Update on the in vivo tolerance and in vitro reduced susceptibility to the antimalarial lumefantrine

Nzila, A., Okombo, J., Ohuma, E., Al-Thukair, A.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2012

Language:

english

File:

PDF, 296 KB

english, 2012

12

Update on genetic markers of quinine resistance in Plasmodium falciparum

John Okombo, Eric Ohuma, Stephane Picot, Alexis Nzila

Journal:

Molecular and Biochemical Parasitology

Year:

2011

Language:

english

File:

PDF, 899 KB

english, 2011

13

Anticancer agents against malaria: time to revisit?

Alexis Nzila, John Okombo, Ruy Perez Becker, Roma Chilengi, Trudie Lang, Tim Niehues

Journal:

Trends in Parasitology

Year:

2010

Language:

english

File:

PDF, 189 KB

english, 2010

14

In Vitro Activity of Antifolate and Polymorphism in Dihydrofolate Reductase of Plasmodium falciparum Isolates from the Kenyan Coast: Emergence of Parasites with Ile-164-Leu Mutation

Kiara, S. M., Okombo, J., Masseno, V., Mwai, L., Ochola, I., Borrmann, S., Nzila, A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2009

Language:

english

File:

PDF, 76 KB

english, 2009

15

Repeat Polymorphisms in the Low-Complexity Regions of Plasmodium falciparum ABC Transporters and Associations with In Vitro Antimalarial Responses

Okombo, J., Abdi, A. I., Kiara, S. M., Mwai, L., Pole, L., Sutherland, C. J., Nzila, A., Ochola-Oyier, L. I.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2013

Language:

english

File:

PDF, 425 KB

english, 2013

16

The Polymorphic Linker Domain of pfmdr1 Is Associated with Resistance-Conferring Mutations in Plasmodium falciparum Populations from East and West Africa

Okombo, J., Zongo, I., Gadalla, N., Bousema, T., Beshir, K. B., Roper, C., Hallett, R., Ochola-Oyier, L. I., Sutherland, C. J.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2013

Language:

english

File:

PDF, 998 KB

english, 2013

17

In Vitro Activities of Quinine and Other Antimalarials and pfnhe Polymorphisms in Plasmodium Isolates from Kenya

Okombo, J., Kiara, S. M., Rono, J., Mwai, L., Pole, L., Ohuma, E., Borrmann, S., Ochola, L. I., Nzila, A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2010

Language:

english

File:

PDF, 628 KB

english, 2010

18

Baseline In Vitro Activities of the Antimalarials Pyronaridine and Methylene Blue against Plasmodium falciparum Isolates from Kenya

Okombo, J., Kiara, S. M., Mwai, L., Pole, L., Ohuma, E., Ochola, L. I., Nzila, A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2012

Language:

english

File:

PDF, 181 KB

english, 2012

19

Chloroquine-containing compounds: a patent review (2010 – 2014)

Njaria, Paul M, Okombo, John, Njuguna, Nicholas M, Chibale, Kelly

Journal:

Expert Opinion on Therapeutic Patents

Year:

2015

Language:

english

File:

PDF, 2.01 MB

english, 2015

20

Parasites and vectors of malaria on Rusinga Island, Western Kenya

Olanga, Evelyn A, Okombo, Lawrence, Irungu, Lucy W, Mukabana, Wolfgang R

Journal:

Parasites & Vectors

Year:

2015

Language:

english

File:

PDF, 412 KB

english, 2015

21

Antimalarial activity of isoquine against Kenyan Plasmodium falciparum clinical isolates and association with polymorphisms in pfcrt and pfmdr1 genes

Okombo, J., Kiara, S. M., Abdirahman, A., Mwai, L., Ohuma, E., Borrmann, S., Nzila, A., Ward, S.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2013

Language:

english

File:

PDF, 159 KB

english, 2013

22

Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya

Okombo, John, Kamau, Alice W., Marsh, Kevin, Sutherland, Colin J., Ochola-Oyier, Lynette Isabella

Journal:

International Journal for Parasitology Drugs and Drug Resistance

Year:

2014

Language:

english

File:

PDF, 1.83 MB

english, 2014

23

Antiplasmodial drug targets: a patent review (2000 – 2013)

Okombo, John, Chibale, Kelly

Journal:

Expert Opinion on Therapeutic Patents

Year:

2015

Language:

english

File:

PDF, 2.10 MB

english, 2015

24

The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine In Vitro Drug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya

Ochola-Oyier, Lynette Isabella, Okombo, John, Mwai, Leah, Kiara, Steven M., Pole, Lewa, Tetteh, Kevin K. A., Nzila, Alexis, Marsh, Kevin

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 2.34 MB

english, 2015

25

Malaria in the Era of Food Fortification With Folic Acid

Nzila, A., Okombo, J., Hyde, J.

Journal:

Food and Nutrition Bulletin

Year:

2016

Language:

english

File:

PDF, 164 KB

english, 2016

26

Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population

Ochola-Oyier, Lynette Isabella, Okombo, John, Wagatua, Njoroge, Ochieng, Jacob, Tetteh, Kevin K., Fegan, Greg, Bejon, Philip, Marsh, Kevin

Journal:

Malaria Journal

Year:

2016

Language:

english

File:

PDF, 1.78 MB

english, 2016

27

Mono- and polynuclear ferrocenylthiosemicarbazones: Synthesis, characterisation and antimicrobial evaluation

Baartzes, Nadia, Stringer, Tameryn, Okombo, John, Seldon, Ronnett, Warner, Digby F., de Kock, Carmen, Smith, Peter J., Smith, Gregory S.

Journal:

Journal of Organometallic Chemistry

Year:

2016

Language:

english

File:

PDF, 348 KB

english, 2016

28

Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics

Stringer, Tameryn, De Kock, Carmen, Guzgay, Hajira, Okombo, John, Liu, Jenny, Kanetake, Sierra, Kim, Jihwan, Tam, Christina, Cheng, Luisa W., Smith, Peter J., Hendricks, Denver T., Land, Kirkwood M.,

Journal:

Dalton Transactions

Year:

2016

Language:

english

File:

PDF, 660 KB

english, 2016

29

Early metabolic profiling of pyrido[1,2-a]benzimidazoles in mouse liver microsomes by LC-MS/MS

Brunschwig, Christel, Singh, Kawaljit, Barnard, Linley, Ndubi, Ferdinand, Okombo, John, Njoroge, Mathew, Wiesner, Lubbe, Chibale, Kelly

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2017

Language:

english

File:

PDF, 109 KB

english, 2017

30

Antimalarial Pyrido[1,2- a ]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

Singh, Kawaljit, Okombo, John, Brunschwig, Christel, Ndubi, Ferdinand, Barnard, Linley, Wilkinson, Chad, Njogu, Peter M., Njoroge, Mathew, Laing, Lizahn, Machado, Marta, Prudêncio, Miguel, Reader, Jan

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 961 KB

english, 2017

31

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

Dhingra, Satish K., Redhi, Devasha, Combrinck, Jill M., Yeo, Tomas, Okombo, John, Henrich, Philipp P., Cowell, Annie N., Gupta, Purva, Stegman, Matthew L., Hoke, Jonathan M., Cooper, Roland A., Winzel

Journal:

Year:

2017

Language:

english

File:

PDF, 1.69 MB

english, 2017

32

Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery

Okombo, John, Chibale, Kelly

Journal:

Accounts of Chemical Research

Year:

2017

Language:

english

File:

PDF, 4.26 MB

english, 2017

33

4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice

Joshi, Mukesh C., Okombo, John, Nsumiwa, Samkele, Ndove, Jeffrey, Taylor, Dale, Wiesner, Lubbe, Hunter, Roger, Chibale, Kelly, Egan, Timothy J

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 913 KB

english, 2017

34

RECENT UPDATES IN THE DISCOVERY AND DEVELOPMENT OF NOVEL ANTIMALARIAL CANDIDATES

Okombo, John, Chibale, Kelly

Journal:

Year:

2018

Language:

english

File:

PDF, 1.28 MB

english, 2018

35

Correction: Recent updates in the discovery and development of novel antimalarial drug candidates

Okombo, John, Chibale, Kelly

Journal:

Year:

2018

Language:

english

File:

PDF, 140 KB

english, 2018

36

Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action

Kumar, Malkeet, Okombo, John, Mambwe, Dickson, Taylor, Dale, Lawrence, Nina, Reader, Janette, Watt, Mariëtte van der, Fontinha, Diana, Sanches-Vaz, Margarida, C Bezuidenhout, Belinda, Lauterbach, Sonj

Journal:

ACS Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 624 KB

english, 2018

37

Antimalarial Pyrido[1,2-a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation and Reactive Metabolite Trapping Studies

Okombo, John, Brunschwig, Christel, Singh, Kawaljit, Dziwornu, Godwin Akpeko, Barnard, Linley, Njoroge, Mathew, Wittlin, Sergio, Chibale, Kelly

Journal:

ACS Infectious Diseases

Year:

2019

Language:

english

File:

PDF, 391 KB

english, 2019

38

Semisynthetic Antimycobacterial C-3 Silicate and C-3/ C-21 Ester Derivatives of Fusidic Acid: Pharmacological Evaluation and Stability Studies in Liver Microsomes, Rat Plasma and Mycobacterium tuberculosis culture

Njoroge, Mathew, Kaur, Gurminder, Espinoza-Moraga, Marlene, Wasuna, Antonina, Dziwornu, Godwin Akpeko, Seldon, Ronnett, Taylor, Dale, Okombo, John, Warner, Digby F., Chibale, Kelly

Journal:

ACS Infectious Diseases

Year:

2019

Language:

english

File:

PDF, 349 KB

english, 2019

39

Structure and Drug Resistance of the Plasmodium Falciparum Transporter PfCRT

Kim, Jonathan, Zi Tan, Yong, Wicht, Kathryn J., Erramilli, Satchal K., Dhingra, Satish K., Okombo, John, Vendome, Jeremie P., Hagenah, Laura M., Giacometti, Sabrina I., Potter, Clinton S., Carragher,

Journal:

Biophysical Journal

Year:

2020

File:

PDF, 46 KB

2020

40

Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity

Singh, Kawaljit, Kaur, Gurminder, Shanika, Petrus Siningu, Dziwornu, Godwin Akpeko, Okombo, John, Chibale, Kelly

Journal:

Bioorganic & Medicinal Chemistry

Year:

2020

File:

PDF, 502 KB

2020

41

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

Harding, Clare R., Sidik, Saima M., Petrova, Boryana, GnÃ¤dig, Nina F., Okombo, John, Herneisen, Alice L., Ward, Kurt E., Markus, Benedikt M., Boydston, Elizabeth A., Fidock, David A., Lourido, Sebast

Journal:

Nature Communications

Year:

2020

File:

PDF, 2.04 MB

2020